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Arsenic's toxicity comes from the affinity of arsenic(III) oxides for thiols. Thiols, in the form of cysteine residues and cofactors such as lipoic acid and coenzyme A, are situated at the active sites of many important enzymes. Rifampicin is the most powerful known inducer of the hepatic cytochrome P450 enzyme system, including isoenzymes CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP3A4, CYP3A5, and CYP3A7. It increases metabolism of many drugs and as a consequence, can… Nasal secretion are not adequately cleared with clinical manifestation of nasal congestion, sinus pressure, post-nasal dripping, and headache. 2017 Principles of Pharmacology The Pathophysiologic Basis of Drug Therapy, 4th Edition 2016 Workbook and Lab Manual for Mosbys Pharmacy Technician Principles and Practice, 4th 2016 Usmle Step 1 Lecture Notes 2016 Pharmacology 2016 Top 300… Fig 3 Association between gain of function CYP2C19*17 polymorphisms with major adverse cardiovascular events (MACE) or stent thrombosis in patients with coronary artery disease receiving clopidogrel treatment.